In a very recent study, we documented the identification and the characterization of a completely new atypical opioid receptor with special detrimental regulatory Attributes toward opioid peptides.1 Our outcomes showed that ACKR3/CXCR7, hitherto often known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can also be a wide-spect